Prevent Heartworm Disease In Your Dog

HEARTGARD® Plus (ivermectin/pyrantel) prevents the invisible threat of heartworm disease and treats and controls five species of intestinal worms.

Dog running to catch ball on grass, person in shorts behind him.
dog playing
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#1 Vet-Recommended1

With more than 2 billion doses prescribed, HEARTGARD Plus is the #1 choice of vets for both their patients and their own dogs.1-3

#1 Dog-Preferred Chew4

Dogs love the only real-beef chew, making monthly dosing easy and delicious.5 Studies show that more dogs choose it over any other oral heartworm disease prevention.4


HEARTGARD Plus doesn’t just prevent heartworm disease for dogs 6 weeks of age and older, it also treats and controls hookworms and roundworms.†6,7

Veterinarian with a dog Veterinarian with a dog
I have been using HEARTGARD Plus for over twenty years to prevent heartworm disease and control intestinal parasites in my patients. It has been proven to not only be a safe and effective preventive, but it is also a joy to administer as it is a tasty beef chew.
Joseph Zuckerman, DVM
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Get Prevention From Your Vet

HEARTGARD Plus is #1 vet-recommended for a reason.1 Once your dog has a negative heartworm test and prescription from your vet, you can purchase HEARTGARD Plus in clinic or through their online store.
Use the search tool below to get started.

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map of heartworm risk for dogs

The Risk of Heartworm Disease is Real

Heartworm disease has been diagnosed in all 50 states.8 And just one bite from an infected mosquito can transmit this potentially deadly disease to your dog. The risk is real. That’s why vets recommend using monthly heartworm disease prevention all year long.

dog running in park

Hookworms and Roundworms Are Unexpected Threats

Your dog can get hookworms and roundworms by stepping in contaminated soil at the park or ingesting them in your own backyard. Luckily, HEARTGARD Plus treats and controls three species of hookworms and two species of roundworms. Learn why there’s more to love in the only real-beef chew.

package of HeartGard and NexGard next to each other
NexGard product

Double the Delight

Add Flea & Tick Protection to Your Monthly Routine

HEARTGARD Plus is the #1 vet-recommended heartworm disease preventive in a delicious real-beef chew—and it pairs perfectly with #1 vet-recommended
NexGard® (afoxolaner).1,9 And the fact is, dogs love the tastes of both.5,10 That’s two tasty chews to double your dog’s dosing delight each month.

IMPORTANT SAFETY INFORMATION: NexGard is for use in dogs only. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for Full Prescribing Information or visit


Protect With Two
SAVE $75
NexGard and HeartGard products NexGard and HeartGard products
Save Big When You Buy Two
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Get a $75 rebate on your qualifying purchases of either NexGard® (afoxolaner) or a FRONTLINE® Brand Product and HEARTGARD® Plus (ivermectin/pyrantel). Download and present this coupon to your vet. 

Save on Prevention
HeartGard Product HeartGard Product
Get Your Rebate
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Buy 12 doses of HEARTGARD® Plus (ivermectin/pyrantel) and enjoy a $15 rebate: Simply download the coupon and take it to your vet.

Fleas and ticks are threats to your dog, too. Pair up HEARTGARD Plus with powerful flea and tick protection.